Protein Tyrosine Phosphatases: Structure, Signaling and Drug Discovery by Lalima

Description: Protein Tyrosine Phosphatases by Lalima G. Ahuja Reversible protein phosphorylation is one of the key mechanisms for cell signaling. Protein Tyrosine Kinases serve as the signaling currency of the cell, while Protein Tyrosine Phosphatases (PTPs) ensure homeostasis, which is critical to cell surv FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies. This book describes these signaling enzymes using the molecular details of their structure and mechanistic function. Various subtypes of cysteine-based Class I, II, III and the Haloacid dehalogenase related Class IV protein tyrosine phosphatases have been illustrated and explained. The superfamily of proteins is also described vis-a-vis its complimentary protein phosphoserine/phosphoserine phosphatases. Membrane bound receptor forms and the cytosolic non-receptor protein tyrosine phosphatases have been described for their biological function. This book serves as a reference for any reader looking to understand the sequence features, structural elements, molecular mechanism and cellular function of this superfamily of signaling enzymes. Author Biography Lalima G. Ahuja, UC San Diego, San Diego, CA, USA. Table of Contents - Tyrosine Phosphorylation in Cell Signaling: Discovery and Beyond- Protein Tyrosine Phosphatase Super-Family of Proteins- The PTP-Fold: Conserved Structure and Enzyme Mechanism-The Bi-Domain RPTPs- Modes of PTP Regulation Seen in Signaling- Role of PTPs in Metabolism: PTP1B as the Prototype- RPTPs in the Immune System: Special Role of CD45- RPTPs in Axon Guidance- Approaches to Study PTPs in Live Cells- Role of PTPs in Host-Pathogen Interactions: Prokaryotic PTPs- PTP Inhibitors in Drug Discovery: Conservative Approaches and New Frontiers Long Description Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies. This book describes these signaling enzymes using the molecular details of their structure and mechanistic function. Various subtypes of cysteine-based Class I, II, III and the Haloacid dehalogenase related Class IV protein tyrosine phosphatases have been illustrated and explained. The superfamily of proteins is also described vis-a-vis its complimentary protein phosphoserine/phosphoserine phosphatases. Membrane bound receptor forms and the cytosolic non-receptor protein tyrosine phosphatases have been described for their biological function. This book serves as a reference for any reader looking to understand the sequence features, structural elements, molecular mechanism and cellular function of this superfamily of signaling enzymes. Details ISBN3110426439 Author Lalima G. Ahuja Pages 296 Publisher De Gruyter Year 2018 ISBN-10 3110426439 ISBN-13 9783110426434 Format Hardcover Publication Date 2018-10-08 Imprint De Gruyter Subtitle Structure, Signaling and Drug Discovery Place of Publication Berlin Country of Publication Germany DEWEY 572.6 Short Title Protein Tyrosine Phosphatases Language English UK Release Date 2018-10-08 Illustrations 15 Tables, black and white; 100 Illustrations, black and white Alternative 9783110421842 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:126534385;

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